By the Peptide Insider Research Desk · Research-Use Only
The query string 5 amino 1mq generates more than a dozen orthographic variants across research-compound catalogues—5-amino-1mq., 5 amino-1mq, five amino 1mq, 5 amino imq, 5-amino-1 mq, 5- amino 1mq and 5 amino mq1 among them. Each resolves to a single canonical entity: 5-amino-1-methylquinolinium (CAS 63417-28-5, MW 158.18 g mol−1), a cell-permeable, small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) [1]. This review maps those search-string variants to the established pharmacological identity, surveys the preclinical evidence base, and addresses the recurring catalogue question "is 5 amino 1mq a peptide" with a definitive structural answer. All information below is strictly for research reference; it is not intended for human or veterinary use.
Query Orthography Table
The table below classifies every uncovered CSV variant by transcription mechanism and assigns an RUO scope status. Strings that resolve to the canonical compound are Recorded-as-nomenclature; strings tied to dosing, pricing or promotion are Declined.
| Search String (Verbatim CSV) | Transcription Mechanism | Canonical Resolution | RUO Scope Status |
|---|---|---|---|
| 5 amino 1mq for sale | Commercial qualifier | 5-Amino-1MQ | Declined – sourcing |
| 5 amino imq | Character transposition (MQ → IMQ) | 5-Amino-1MQ | Recorded-as-nomenclature |
| 5 amino 1mq injection | Route-of-administration tag | 5-Amino-1MQ | Declined – administration |
| 5-amino-1mq. | Trailing punctuation artifact | 5-Amino-1MQ | Recorded-as-nomenclature |
| 5 amino-1mq | Partial hyphenation | 5-Amino-1MQ | Recorded-as-nomenclature |
| peptide 5 amino 1mq | Category-prefix misattribution | 5-Amino-1MQ (not a peptide) | Recorded-as-nomenclature |
| 5- amino 1mq | Hyphen-space insertion | 5-Amino-1MQ | Recorded-as-nomenclature |
| five amino 1mq | Numeral-to-word substitution | 5-Amino-1MQ | Recorded-as-nomenclature |
| 5 aminos | Truncation + plural | Ambiguous (5-Amino-1MQ or amino acids) | Recorded-as-nomenclature |
| what is 5 amino 1mq used for | Question-form query | 5-Amino-1MQ | Recorded-as-nomenclature |
| 5 amino acids | Class-level homonym | Not 5-Amino-1MQ; generic biochemistry term | Recorded-as-nomenclature |
| 5-amino-1 mq | Space insertion before MQ | 5-Amino-1MQ | Recorded-as-nomenclature |
| 5 amino 1mq peptide injection | Category + route tag | 5-Amino-1MQ (not a peptide) | Declined – administration |
| 5-amino-1mq powder | Form-factor descriptor | 5-Amino-1MQ | Recorded-as-nomenclature |
| 5 amino pentanoic acid | Homonym – separate compound | 5-Aminopentanoic acid (δ-aminovaleric acid) | Recorded-as-nomenclature |
| what does 5-amino-1mq do | Question-form query | 5-Amino-1MQ | Recorded-as-nomenclature |
| 5 amino-1mq peptide | Category misattribution | 5-Amino-1MQ (not a peptide) | Recorded-as-nomenclature |
| 5 amino 1mq injectable | Route tag | 5-Amino-1MQ | Declined – administration |
| injectable 5 amino 1mq | Inverted route tag | 5-Amino-1MQ | Declined – administration |
| 5 amino 1mq powder | Form-factor descriptor | 5-Amino-1MQ | Recorded-as-nomenclature |
| 5-amino-1mq what is it | Question-form query | 5-Amino-1MQ | Recorded-as-nomenclature |
| is 5 amino 1mq a peptide | Classification query | 5-Amino-1MQ (not a peptide) | Recorded-as-nomenclature |
| 5 amino 1mq safe | Safety-intent query | 5-Amino-1MQ | Recorded-as-nomenclature |
| 5 1mq | Maximal truncation | 5-Amino-1MQ | Recorded-as-nomenclature |
| 1 amino 1mq | Numeral swap (5 → 1) | 5-Amino-1MQ | Recorded-as-nomenclature |
| 5-amino-1mq 5mg | Mass descriptor | 5-Amino-1MQ | Declined – dosing |
| 5 amino mq1 | Character swap (1MQ → MQ1) | 5-Amino-1MQ | Recorded-as-nomenclature |
| 5-amino-mq | Numeral drop | 5-Amino-1MQ | Recorded-as-nomenclature |
| 5-amino 1mq 50mg | Mass descriptor | 5-Amino-1MQ | Declined – dosing |
| 5 amino 1-mq | Shifted hyphenation | 5-Amino-1MQ | Recorded-as-nomenclature |
| 5 amino 1 methylquinolinium | Full IUPAC, spaces only | 5-Amino-1MQ | Recorded-as-nomenclature |
| 5-amino-1-methylquinolinium | Full IUPAC, hyphenated | 5-Amino-1MQ | Recorded-as-nomenclature |
Is 5-Amino-1MQ a Peptide?
The search string "is 5 amino 1mq a peptide" appears frequently in catalogue queries and deserves explicit clarification. A peptide is defined as a short chain of amino-acid residues linked by amide (peptide) bonds, typically 2–50 residues in length. 5-Amino-1MQ is a substituted quinolinium cation (C10H10N2, MW 158.18 g mol−1) with a fused bicyclic aromatic scaffold [1]. It contains:
- Zero amino-acid residues
- Zero amide (peptide) bonds
- No polypeptide backbone
Catalogues that list 5 amino-1mq peptide or peptide 5 amino 1mq under peptide headings are using the term as a commercial category label rather than a structural descriptor. Structurally, 5-Amino-1MQ belongs to the quinolinium small-molecule class, analogous to how MK-677 (ibutamoren) appears in peptide catalogues despite being a non-peptide ghrelin-receptor mimetic [2].
NNMT: The Target Enzyme
Nicotinamide N-methyltransferase (NNMT; EC 2.1.1.1) is a cytosolic phase-II conjugation enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide, producing 1-methylnicotinamide (1-MNA) and S-adenosylhomocysteine (SAH) [3,4]. NNMT expression is elevated in the white adipose tissue of obese subjects, correlating with body-mass index in both murine and human tissue samples [3,5]. The enzyme sits at a metabolic crossroads controlling two critical pools:
- NAD+ salvage: Nicotinamide is the primary substrate for nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting step of the NAD+ salvage pathway. NNMT competes for the same substrate, effectively draining nicotinamide away from NAD+ synthesis [3,6].
- Universal methylation: By consuming SAM, NNMT reduces the methyl-donor pool available for DNA, histone and protein methylation reactions that regulate adipocyte differentiation and lipid-metabolism gene expression [4,7].
Mechanism of 5-Amino-1MQ Inhibition
Neelakantan et al. (2018) characterised 5-amino-1-methylquinolinium as a selective, cell-permeable, competitive inhibitor of NNMT [1]. The compound occupies the enzyme active site, preventing the nicotinamide-to-1-MNA conversion. Two principal downstream consequences have been documented in preclinical systems:
- NAD+ restoration. By sparing nicotinamide from NNMT-mediated methylation, 5-Amino-1MQ redirects substrate into the NAMPT-catalysed salvage pathway, elevating intracellular NAD+ levels. Increased NAD+ supports mitochondrial oxidative phosphorylation and engages sirtuin (SIRT1–SIRT7) deacetylase activity [1,6].
- SAM conservation. Reduced SAM consumption by NNMT preserves the cellular methyl-donor pool, maintaining epigenetic methylation patterns that govern adipocyte phenotype and metabolic gene expression [1,4].
Preclinical Evidence Table
| Research Model | Signal Vector | Key Finding | Ref |
|---|---|---|---|
| Diet-induced obese (DIO) C57BL/6 mice | Body weight, WAT mass, food intake | Significant body-weight and fat-mass reduction without appetite suppression | [1] |
| DIO mice, NNMT genetic knockout | Insulin sensitivity, glucose tolerance | NNMT deficiency improved insulin sensitivity on HFD; glucose tolerance unchanged | [8] |
| Murine 3T3-L1 pre-adipocytes | NAD+/NADH ratio, lipid droplet area | NNMT inhibition reduced lipid accumulation and shifted adipocyte energy phenotype | [1,9] |
| DIO mice + reduced-calorie diet | Cecal microbiome composition | NNMT inhibition + low-fat diet shifted microbiome toward lean-control profile | [10] |
| HeLa cell line | Cell proliferation | Small-molecule NNMT inhibitor showed anti-proliferative activity in cervical cancer cells | [11] |
| DIO mice, Kraus et al. NNMT knockdown | WAT NNMT mRNA, adiposity, energy expenditure | Antisense knockdown protected against diet-induced obesity; increased energy expenditure | [3] |
| Rat plasma pharmacokinetics | Oral bioavailability, LC-MS/MS | Validated LC-MS/MS assay for 5-Amino-1MQ; oral bioavailability characterised | [12] |
| Mouse adipose (WAT), glucose challenge | NNMT expression vs body weight | Body weight predicted WAT NNMT activity; glucose regulated NNMT expression | [5,9] |
| HFpEF mouse model (cardiac) | Cardiac function, structure | NNMT inhibition improved cardiac function in heart-failure model | [13] |
The 5-Amino Pentanoic Acid Disambiguation
The CSV string 5 amino pentanoic acid (δ-aminovaleric acid; CAS 660-88-8; C5H11NO2; MW 117.15) is a straight-chain ω-amino acid unrelated to the quinolinium scaffold of 5-Amino-1MQ. It appears in catalogue searches because the shared "5 amino" prefix triggers co-retrieval. Researchers should note that δ-aminovaleric acid is a GABA homologue studied in neurotransmitter metabolism, not an NNMT inhibitor [1].
Structural Class Comparison
Because 5 amino-1mq peptide and 5 amino 1mq peptide injection appear as frequent query strings, the table below positions 5-Amino-1MQ alongside true peptide-class compounds and another non-peptide catalogue neighbour for structural disambiguation.
| Compound | MW (g mol−1) | Structural Class | Peptide Bonds | NNMT Involvement |
|---|---|---|---|---|
| 5-Amino-1MQ | 158.18 | Quinolinium cation | 0 | Competitive inhibitor |
| BPC-157 | 1 419.53 | Pentadecapeptide | 14 | None reported |
| GHK-Cu | 403.93 | Tripeptide–copper complex | 2 | None reported |
| MK-677 (Ibutamoren) | 528.67 | Non-peptide spiropiperidine | 0 | None reported |
Frequently Asked Questions
What is 5 amino 1mq used for?
In preclinical research, 5-Amino-1MQ is used as a selective NNMT inhibitor to study NAD+ salvage, SAM-dependent methylation, adipocyte metabolic reprogramming and energy-expenditure pathways in diet-induced obesity models [1,3]. It is a research-grade tool compound and is not approved for clinical use.
What does 5-amino-1mq do?
5-Amino-1MQ competitively blocks NNMT, preventing the enzyme from methylating nicotinamide. This preserves nicotinamide for NAD+ synthesis via NAMPT and conserves SAM for epigenetic methylation reactions, collectively shifting adipocyte metabolism toward higher energy expenditure in preclinical models [1,4].
Is 5 amino 1mq a peptide?
No. 5-Amino-1MQ (C10H10N2, MW 158.18) is a substituted quinolinium small molecule. It contains zero amino-acid residues and zero peptide bonds. Catalogue listings under "peptide" headings reflect a commercial category convention, not structural classification [1,2].
Is 5 amino 1mq safe?
No completed human clinical trials have established the safety profile of 5-Amino-1MQ as of the date of this review. All available pharmacological and toxicological data derive from in vitro cell-culture and in vivo rodent models [1,8]. Researchers should consult institutional biosafety protocols before handling this compound.
What is 5-amino-1mq what is it?
5-Amino-1MQ is the abbreviated name for 5-amino-1-methylquinolinium, a small-molecule NNMT inhibitor first characterised by Neelakantan et al. (2018). Alternative search forms include 5 1mq, 5 amino mq1, 5-amino-mq, five amino 1mq, 1 amino 1mq and 5 amino 1 methylquinolinium—all resolving to CAS 63417-28-5 [1].
Where to Source 5-Amino-1MQ for Research
Researchers procuring 5-Amino-1MQ for preclinical investigation should verify supplier certificates of analysis (CoA), batch-specific HPLC purity (≥ 98 %) and mass-spectrometry confirmation of the quinolinium cation identity. The following suppliers stock research-grade material: Short Chain Aminos (primary catalogue), BioPep, Catalyst Research and Apex Research Services. No vendor listed herein has been evaluated, endorsed or verified by Peptide Insider; inclusion reflects catalogue availability only.
Works Cited
- Neelakantan H et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochem Pharmacol. 2018;147:141–152. PMID 29155147.
- Ruf S et al. Novel tricyclic small molecule inhibitors of Nicotinamide N-methyltransferase for the treatment of metabolic disorders. Sci Rep. 2022;12:15440. PMID 36104373.
- Kraus D et al. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature. 2014;508(7495):258–262. PMID 24717514.
- Roberti A et al. Nicotinamide N-methyltransferase: At the crossroads between cellular metabolism and epigenetic regulation. Mol Metab. 2021;45:101165. PMID 33453420.
- Rudolphi B et al. Body weight predicts Nicotinamide N-Methyltransferase activity in mouse fat. Endocr Res. 2018;43(1):55–63. PMID 29035138.
- Trammell SA, Brenner C. NNMT: A Bad Actor in Fat Makes Good in Liver. Cell Metab. 2015;22(2):200–201. PMID 26244929.
- Sun WD et al. Nicotinamide N-methyltransferase (NNMT): a novel therapeutic target for metabolic syndrome. Front Pharmacol. 2024;15:1410479. PMID 38919254.
- Brachs S et al. Genetic Nicotinamide N-Methyltransferase (Nnmt) Deficiency in Male Mice Improves Insulin Sensitivity in Diet-Induced Obesity but Does Not Affect Glucose Tolerance. Diabetes. 2019;68(3):527–535. PMID 30552109.
- Ehebauer F et al. Glucose availability regulates nicotinamide N-methyltransferase expression in adipocytes. Life Sci. 2020;248:117474. PMID 32112869.
- Dimet-Wiley A et al. Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice. Sci Rep. 2022;12:1426. PMID 35013352.
- Akar S et al. Small molecule inhibitor of nicotinamide N-methyltransferase shows anti-proliferative activity in HeLa cells. J Obstet Gynaecol. 2021;41(7):1143–1146. PMID 33645410.
- Awosemo O et al. Development & validation of LC-MS/MS assay for 5-amino-1-methyl quinolinium in rat plasma. J Pharm Biomed Anal. 2021;205:114255. PMID 34304009.
- Li S et al. Nicotinamide-N-methyltransferase inhibition improves cardiac function and structure in a heart failure with preserved ejection fraction mouse model. Pharmacol Res. 2025;213:107820. PMID 40484359.
This article is strictly for research reference and informational purposes. It does not constitute medical advice, dosing guidance, or endorsement of any compound for human or veterinary use. All compounds discussed are research-grade materials intended for qualified laboratory investigation only. Researchers must comply with applicable institutional, local and national regulations governing the acquisition and use of research compounds.